Antioxidant Neolignans from Cordia americana

FERNANDEZ, LR; CIRIGLIANO, A; FABANI, MP; LIMA, B; ALBERTI, S; KRAMER, F; TAPIA, A; CABRERA, G; PALERMO, JA; SÁNCHEZ, M

PLANTA MEDICA

GEORG THIEME VERLAG KG

Año: 2013 vol. 79 p. 1724 - 1729

0032-0943

Five new neolignans with a bicyclo[2.2.2]octene framework were isolated from an ethanolic extract of the bark of Cordia americana (L.) Gottschling & J. S. Mill. The structures and relative configurations of the compounds were elucidated by a combination of spectroscopic methods. All the isolated compounds showed good antioxidant activities in the DPPH radical scavenging (0.5?100 µg/mL) and Ferric-reducing antioxidant power (FRAP, 1?100 µg/mL) assays. One of the compounds displayed mild fungistatic activity at 0.1 µmol/spot against Fusarium virguliforme while, at the same time, all compounds were inactive against several strains of gram (+) and gram (−) bacteria at all assayed concentrations (10?1000 µg/mL).