Synthesis and biologicalactivity of ring-A difluorinated brassinosteroids

ACEBEDO, SL; ALONSO, F; GALAGOVSKY, L; JAVIER A. RAMIREZ;

STEROIDS

ELSEVIER SCIENCE INC

Lugar: Amsterdam; Año: 2011 vol. 76 p. 1016 - 1020

0039-128X

In this paper we report the synthesis of four ring-A difluorinated analogs of brassinosteroids. The bioactivity of these new compounds was evaluated using the rice lamina inclination test. The results show that one of these analogs elicits a bioactivity comparable to that of 28-homocastasterone, a highly active natural brassinosteroid. This finding suggests that both hydroxyls at C-2 and C-3 in active brassinosteroids are involved as hydrogen bond acceptors in their interactions with the cellular receptor.