IFIBYNE 05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
The impact of retroactivity on the input/output static characteristics of a signaling component
Autor/es:
ALEJANDRA C VENTURA; PENG JIANG; ALEXANDER J NINFA; LAUREN VAN WASSENHOVE; SOFIA D MERAJVER; DOMITILLA DEL VECCHIO
Reunión:
Conferencia; ASME Dynamic Systems and Control Conference; 2010
Resumen:
In prior work, we have shown that just as in many engineeringsystems, impedance-like effects appear at the interconnectionof biomolecular systems. These effects are called retroactivity, toextend the notion of impedance to biological systems. Signalingcomponents, such as covalent modification cycles, play a centralrole in the transmission of signals within a cell and from outsidethe cell. They are typically found in highly interconnected architecturesin which a component has several downstream clients.In this paper, we investigate how retroactivity due to downstreamclients affects the input/output steady state characteristics of acovalent modification cycle.
