IFIBYNE 05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Epigenetic mechanisms in long-term memory
Autor/es:
NOEL FEDERMAN
Lugar:
Huerta Grande, Córdoba
Reunión:
Conferencia; IIRCN 2010; 2010
Institución organizadora:
SAN - Taller de Neurociencias
Resumen:
Long-term memory (LTM) consolidation requires mRNA and de novo protein synthesis. Transcriptional activation is controlled by transcription factors, their cofactors and repressors. Cofactors and repressors can regulate gene expression by interacting with basal transcription machinery, remodeling chromatin structure and chemically modifying histones. These last two processes are considered as epigenetic mechanisms.The acetylation is the most studied histone modification related to gene expression regulation. This process is regulated by lysine acetylases (KATs) and deacetylases (KDACs). We use histone acetylation as a model mechanism in order to study the role of epigenetic during LTM formation.We present evidences supporting histone acetylation function during consolidation of context-signal memory in the crab Chasmagnathus, as well as during consolidation of novel object recognition memory in mice. Based on our results, we hypothesize that histone acetylation is a key mechanism in LTM consolidation, functioning as a molecular feature of stronger memories.
