Following the footprints of the reconsolidation process: its role in memory persistence

MARÍA E PEDREIRA

Glasgow

Congreso; FENS Forum 2020; 2020

Federation of European Neuroscience Societies

The ability to make predictions based on stored information is a general coding strategy. Would this capacity imply an important flexibility to rewrite memories as a consequence of a permanent changing world? In the last years, it has been shown that acquired memories can become active and update its content or strength by the labilization-reconsolidation process. In this Lecture, I would like to show you the study of the reconsolidation process of human declarative memories making focus on the neural footprints associated with the strengthening function. Finally, I want to analyze the future avenues whereas the reconsolidation process could also be a therapeutic tool for subjects with mild cognitive impairment or the mechanism on charge of the persistence of memories associated with anxiety disorders. Based on the role that threat-conditioning memory plays in anxiety disorders, the first step implies a global approach analyzing the scope of disrupting threat-conditioning memory reconsolidation of the implicit memory, its declarative contingency and cognitive biases.