IFIBYNE 05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
TRISTETRAPROLIN (TTP) EXPRESSION IS REQUIRED FOR MAINTENANCE OF THE MAMMARY PROGENITOR CELL POPULATION
Autor/es:
MICAELA STEDILE; LOURDES PEREZ CUERVO; ANA RAIMONDI; INES BECKERMAN; MARTÍN GARCÍA SOLÁ; OMAR A. COSO; M. VICTORIA GODDIO; MARÍA VICTORIA MEDINA; EDITH C KORDON
Lugar:
LXII Reunión Annual de la Sociedad Argentina de Investigación Clínica (SAIC Mar del Plata,
Reunión:
Congreso; Reunión Anual SAIC 2019; 2019
Institución organizadora:
SAIC
Resumen:
Messenger RNA (mRNA) stability is regulated mainly by proteins that bind sequences enriched in adenine and uracil in their 3´untranslated regions, called AU-binding proteins (AUBPs). Tristetraprolin (TTP) is an AUBP that promotes mRNA degradation of proteins involved in inflammation, proliferation and tumor invasiveness. In particular, RNA-seq data indicates that TTP is up-regulated in mammary progenitor cells (p
