Angiotensin II: Key rol in mammary gland involution and mammary tumours

SUBERBORDES MARÍA V; WERTHEIMER EVA; LARA, ANGELA; SCHERE-LEVY, CAROLINA; CAMBADOS NADIA; KORDON EDITH

Mar del Plata

Congreso; Reunión anual SAIC 2018; 2018

Angiotensin (Ang) II, the main effector peptide of the renin-angio- tensin system, has been implicated in multiple aspects of cancer progression such as proliferation, migration, invasion, angiogen- esis and metastasis. Our previous studies have shown that AngII through AT1 receptor induces STAT3 activation, epithelial apoptosis and MMP-9 activation during mammary gland involution. The lack of AT1 receptor caused a delay in mammary involution. In this study, we show that AngII through AT1 receptor has a key role as tumour promoter on breast cancer cell lines. We found that AngII induced cell invasion (2 fold change p