Synaptic composition and protein acetylation change during Inhibitory avoidance Consolidation in mice.

MARIA JULIA BUSSO; MARIANO BOCCIA; MARIANO BLAKE; ANGELES SALLES; RAMIRO FREUDENTHAL

Mar del plata

Congreso; San 2015; 2015

SAN

It is well known that synapses are plastic structures involved in processes such synaptic plasticity and memory consolidation. Previous studies show that protein composition of the synapse changes during memory consolidation. There is evidence that synaptic protein composition is, at least partly, modulated by Post-Translational modifications (PTM). Furthermore synaptic plasticity and memory consolidation rely in many cases on these PTM of the proteins composing the synapse. In particular, some of the changes that occur at the synapse during these processes involve a reorganization and protein redistribution. Here we report the conditions to evaluate protein acetylation and composition at the synapse and used the inhibitory avoidance learning task in mice to study a particular type of PTM, the lysine acetylation, during memory consolidation. We evaluate the changes in synaptic protein composition that occur after training, in correlation with changes in protein acetylation.