IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Small animal PET study of memory reconsolidation
Autor/es:
VERÓNICA DE LA FUENTE; CANDELA MEDINA; GERMÁN FALASCO; LEANDRO URRUTIA; SILVIA VÁZQUEZ; ARTURO ROMANO
Lugar:
Mar del Plata
Reunión:
Congreso; XXX Congreso de la Sociedad Argentina de Investigación en Neurociencias; 2015
Institución organizadora:
Sociedad Argentina de Investigación en Neurociencias
Resumen:
After learning, the new information is encoded in neural circuits. For that encoding, neuronal plastic changes occur to stabilize the memory trace, a process termed consolidation. If some cues of the learning event are presented to the subjects after the memory is fully consolidated, the memorytrace can become labile and requires a process of re-stabilization calledreconsolidation. For the past decades, labilization/reconsolidation processes has been studied from behavioral, cellular and molecular approaches but nostudies have emerged to elucidate neural circuits subserving memory dynamics during these processes. Here, we studied the mouse brain from a functional perspective using small-animal Positron Emission Tomography (PET). The main objective was to study functional dynamics after thelabilization/reconsolidation phases ofmemory in contextual fear conditioning in mice. We found differences in glucose consumption mainly in ectorhinal cortex, hippocampus and amygdala in re-exposed animalscompared to non-re-exposed animals. Moreover, animals that only evocated but did not labilized the trace showed differences with mice that labilized and reconsolidated.The differences in glucose consumptions showed a marked temporal and spatial course, and were context-specific. This work opens new insights in the dynamics of activation of different brainareas during memory reconsolidation.