Dynamics of synaptic NF-kappa B during inhibitory avoidance long term memory consolidation

FREUDENTHAL RAMIRO

Huerta Grande

Encuentro; XXVIII CONGRESO ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACION EN NEUROCIENCIAS & Reunión satélite sobre Neurobiología del Comportamiento: ?NeuroetologÍa y Neurobiología de la Memoria en el cono sur? Un homenaje a Héctor Maldonado; 2013

SOCIEDAD ARGENTINA DE INVESTIGACION EN NEUROCIENCIAS

Since the discovery that long term memory is dependent on protein synthesis, several transcription factors have shown to participate in the transcriptional activity needed for its consolidation. NF-kappa B, among them is a constitutive transcription factor whose nuclear activity has proven to be necessary for the consolidation of inhibitory avoidance in mice. This transcription factor has a wide distribution in the nervous system, with a well reported presence in dendrites and synaptic terminals. Here we report changes in synaptosomal NF-kappa B localization and activity of during long term memory consolidation. Activity comparison of synaptosomal and nuclear NF-kappa B, indicates different dynamics for both pools. Possible implication of synaptosomal NF-kappa B redistribution and activity during consolidation are discussed.