Different dimensions of the prediction error as a decisive factor for the triggering of the reconsolidation process

LOPEZ M AGUSTINA; CORTAZA SANTIAGO; FERNANDEZ RODRIGO S; PEDREIRA M EUGENIA; LOPEZ M AGUSTINA; CORTAZA SANTIAGO; FERNANDEZ RODRIGO S; PEDREIRA M EUGENIA; SANTOS M JIMENA; CARBO TANO MARTIN; SANTOS M JIMENA; CARBO TANO MARTIN

NEUROBIOLOGY OF LEARNING AND MEMORY

ACADEMIC PRESS INC ELSEVIER SCIENCE

Año: 2016 vol. 136 p. 210 - 219

1074-7427

The reconsolidation process is the mechanism by which strength and/or content of consolidated memories are updated. Prediction error (PE) is the difference between the prediction made and current events. It is proposed as a necessary condition to trigger the reconsolidation process. Here we analyzed deeply the role of the PE in the associative memory reconsolidation in the crab Neohelice granulata. An incongruence between the learned temporal relationship between conditioned and unconditioned stimuli (CS-US) was enough to trigger the reconsolidation process. Moreover, after a partial reinforced training, a PE of 50% opened the possibility to labilize the consolidated memory with a reminder which included or not the US. Further, during an extinction training a small PE in the first interval between CSs was enough to trigger reconsolidation. Overall, we highlighted the relation between training history and different reactivation possibilities to recruit the process responsible of memory updating.