CONICET | Buscador de Institutos y Recursos Humanos

Recent work evidenced that co-activity of different motoneurons in the leech can be regulated through a network that is centered on a pair of nonspiking (NS) neurons. Here we investigate whether this effect generalizes to different types of motoneurons that display differential co-activity patterns in different motor behaviors: the dorsal longitudinal excitors DE-3 and the dorsal and ventral excitors MN-L. The data indicates that both motoneurons are coupled to the NS neurons through rectifying junctions that are activated when the motoneuron membrane potential becomes more negative than that of the NS, and that they exert an inhibitory synaptic potential on NS via a polysynaptic pathway. In addition, DE-3 and MN-L are linked by junctions that allow mutual excitation but the transmission of excitatory signals from MN-L to DE-3 depended on NS membrane potential. The results indicate that NS neurons can play a central role in orchestrating the co-activity of MNs during motor behaviors.