IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
artículos
Título:
Nonassociative Plasticity Alters Competitive Interactions Among Mixture Components In Early Olfactory Processing
Autor/es:
LOCATELLI FERNANDO; FERNANDEZ PATRICIA; VILLARREAL, FRANCIS.; MEZZINOGLU K; HUERTA R.; GALIZIA G; SMITH BRIAN
Revista:
EUROPEAN JOURNAL OF NEUROSCIENCE
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Lugar: Londres; Año: 2012
ISSN:
0953-816X
Resumen:
Experience
related plasticity is an essential component of networks involved in early
olfactory processing. However, the mechanisms and functions of plasticity in
these neural networks are not well understood. We studied nonassociative
plasticity by evaluating responses to two pure odors (A and X) and their binary
mixture using calcium imaging of odor elicited activity in output neurons of
the honey bee antennal lobe. Unreinforced exposure to A or X produced no change
in the neural response elicited by the pure odors. However, exposure to one
odor (e.g. A) caused the response to the mixture to become more similar to the
other component (X). We also show in behavioral analyses that unreinforced
exposure to A caused the mixture to become perceptually more similar to X.
These results suggest that nonassociative plasticity modifies neural networks
in such a way that it affects local competitive interactions among mixture
components. We used a computational model to evaluate the most likely targets
for modification. Hebbian modification of synapses from inhibitory local
interneurons to projection neurons most reliably produces the observed shift in
response to the mixture. These results are consistent with a model in which the
antennal lobe acts to filter olfactory information according to its relevance
for performing a particular task.