IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
artículos
Título:
Effect of a Nonspiking Neuron on Motor Patterns of the Leech
Autor/es:
MARIANO JULIÁN RODRIGUEZ; RODRIGO JULIÁN ALVAREZ; LIDIA SZCZUPAK
Revista:
JOURNAL OF NEUROPHYSIOLOGY
Editorial:
AMER PHYSIOLOGICAL SOC
Referencias:
Lugar: Bethesda; Año: 2012 vol. 107 p. 1917 - 1924
ISSN:
0022-3077
Resumen:
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Premotor and
motoneurons could play regulatory roles in motor control. We have investigated
the role of a premotor nonspiking (NS) neuron of the leech nervous system in
two locomotive patterns: swimming and crawling. The NS neuron is coupled
through rectifying electrical junctions to all the excitatory motoneurons
examined. In addition, activation of motoneurons evokes chemically mediated
inhibitory responses in NS. During swimming and crawling, the NS membrane
potential (VmNS) oscillated phase-locked to the motor output.
Hyperpolarization or depolarization of NS had no effect on swimming, but
hyperpolarization of NS slowed down the crawling activity and decreased the
motoneuron firing frequency. Depolarization of NS increased the motoneuron
activity and, at stages where the crawling pattern was fading, depolarization
of NS reinstated it. Future work will determine if NS is actually a member of
the central pattern generator or a regulatory element.