Disease-modifying immunotherapy for the management of autoimmune diabetes

CASTRO, CN; BARCALA TABARROZI, AE; ANTUNICA NOGUEROL, M; LIBERMAN, AC; DEWEY, RA; ARZT, E; MORELLI, AE; PERONE, MJ

NEUROIMMUNOMODULATION.

KARGER

Año: 2010 vol. 17 p. 173 - 176

1021-7401

Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease that destroys the insulin-secreting beta-cells of the pancreas. It is now possible to predict those candidates that will progress to T1D before the full onset of the disease. Prevention of uncontrollable autoimmunity against beta-cells in therapies for T1D is mandatory to preserve the beta-cell mass. Therefore, immunomodulatory strategies directed to inhibiting the activity of self-reactive T cell clones as well as induction of regulatory T cells would be beneficial for prevention of T1D or recurrence of beta-cell autoimmunity against islet cell allografts. Copyright © 2010 S. Karger AG, Basel.