NANOHYBRID OF MAGNETIC-UPCONVERSION NANOPARTICLES INTEGRATED INTO m-SILICA AS CANDIDATE FOR PDT

MARÍA GONZÁLEZ-BÉJAR; MYKHAYLO SEMENOV PETROV; JULIA PEREZ-PRIETO; DANIEL A. CAMINOS; IGNACIO ROSA-PARDO; RAQUEL E. GALIAN; NÉSTOR ESTEBANEZ

Valencia

Conferencia; UPCON18: 2nd Conference and Spring School on Properties, Design and Applications of Upconversion Nanomaterials; 2018

ICMOL-Universidad de Valencia-COST

Integrationof different functional materials to lead to materials with relevant features andapplications is a subject of increasing interest. Our group has recentlydeveloped a nanohybrid consisting of a few number of Fe3O4@Aunanoparticles encapsulated into mesoporous silica (m-silica, MSN) and with a PDT photosensitizer, specifically RoseBengal, anchored to the pores1. An efficient singlet oxygenformation was obtained upon excitation of the nanohybrid with visible light.The aim of this work was i) the preparation of a new biocompatible nanohybrid,comprising magnetic and luminescent nanoparticles within m-silica, anddecorated with a porphyrin, and ii) the study of its efficiency to generatesinglet under NIR light excitation. RESULTS Individualmagnetic Fe3O4 nanoparticles (MNP) and luminescentcore-shell β-NaYF4:Yb3+/Er3+:NaYF4 upconversion nanoparticles (UCNP) weresynthesized using already reported methodologies2, 3. First, the incorporation of bothNPs into m-silica was optimized and the MNP-UC@MSN nanohybrid was characterizedby different techniques, such as transmission electron microscopy (Fig. 1),infrared spectroscopy FTIR, and fluorescence. Then, the MNS surface was functionalizedwith tetrakis(4-carboxyphenyl)porphyrin. Finally, the nanohybrid was tested assinglet oxygen photosensitizer under NIR excitation. Figure 1. TEM images (left, scale bar 500 nm)and schematic representation of MNP-UCNP@MSN (right).CONCLUSIONS Anew multifunctional nanohybrid exhibiting magnetic and luminescent features anddecorated with a porphyrin anchored to its surface proved to be efficient inthe generation of singlet oxygen upon NIR excitation. The involved mechanismswill be discussed. ACKNOWLEGMENTSWe thank the MEC for funding (project CTQ2014-60174-P, partially co-financedwith FEDER funds, Maria de Maeztu: MDM-2015-0538, RyG contract to MGB, contractto NE).