Supramolecular chemistry applied to Nanoparticles design: Sensors and Drug delivery systems. (Review article).

D. GONTERO ; A. G. BRACAMONTE*; D. BROUARD; A. V. VEGLIA*; M. LESSARD-VIGER ; D. BOUDREAU*

MICROCHEMICAL JOURNAL

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2016 vol. 130 p. 316 - 328

0026-265X

Supramolecular chemistry is a well-known field that, applied to analytical chemistry gives, as a result, supramolecularanalytical chemistry. Based in its interactions, this field is part of a new area of nanomedicine, called supramolecularmedicine. In order to improve the detection of biological molecules to be applied in cell tracking,health problems and biological events, supramolecular chemistry has lately been combined with supra-nanostructuresdesign. In other words, supramolecular systems can be used as tools in the nano-design of nano-systemsfor the bio-recognition of biological events, host of ions and organic moleculeswith different structures andintrinsic chemical properties, as enhancer of the solubility, modification of surface properties, bioconjugation forthe nanoparticles design, etc. The versatility of these types of systems is very wide; specifically their use in thenanosensor design using nanoparticles was not highly applied. However, in the last years, the bioconjugationof supramolecular systems, such as macrocycles and antibodies, and proteinswith metallic and polymeric nanoparticleshas increased, aswell as the development of supramolecular nanoparticles based on host guest interactionsof macrocycles. Therefore, this review focuses on the application of supramolecular systems as signaltransducers in the nanosensors design for bio-recognition events, detection of biological targets, and drug deliverysystem. These nanosystems, as transducer hosts and building blocks, are linked to metallic and polymericnanoparticles; and organize molecular systems for different applications.