Novel potential nanostructures for photodynamic therapy

P. F. GARCIA; L. A. PÉREZ; E. A. CORONADO; G. A. ARGUELLO

Photodiagnosis Photodynamic Therapy

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2015 vol. 12 p. 329 - 329

1572-1000

Dimers could be very effective for generating photothermaldamage because the excitation of the surface plasmon resonancePR) results in a temperature increase near the NP surface. Inaddition they present the advantage that the frequency of the SPRresonance can be tuned by using different NPs sizes or interparticle separations. The surface enhanced Raman scattering (SERS)response of the complex located in the gap of the NP aggregates results in an analytical SERS enhancement factor of 100,000. Thisfeature corroborates that the ruthenium complex is indeed located between nanoparticles. An additional confirmation of this fact hasbeen performed using Transmission Electron Microscopy (TEM), in which dimers, trimers and other aggregates where found. A kineticstudy of the NP aggregation process, followed by the evolution of the UV vis extinction spectra, has been also performed. The resultsshow that in a first stage it exist isolated NPs, later we can see theformation of dimers and trimers and in a third stage we observeNP-chains. We also perform fluorescence quenching experiments,finding Stern Volmer constants around Ksv =4×1011M−1. Theseconstants involved a phenomenon called superquenching, which means a massive deactivation of the emission of the complex.constants involved a phenomenon called superquenching, which means a massive deactivation of the emission of the complex.Ksv =4×1011M−1. Theseconstants involved a phenomenon called superquenching, which means a massive deactivation of the emission of the complex.