INFIQC 05475
INSTITUTO DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Unidad Ejecutora - UE
artículos
Título:
Microwave Assisted Synthesis of ethyl-quinolon-4-one-3-carboxylates and Hydrolysis to quinolon-4-one-3-carboxylic Acids
Autor/es:
MALVACIO, IVANA; D. MARIANO VERA; ELIZABETH L. MOYANO
Revista:
Current Microwave Chemistry
Editorial:
Bentham Science Publishers
Referencias:
Lugar: Oak Park, Il; Año: 2014 vol. 1 p. 52 - 58
ISSN:
2213-3356
Resumen:
A fast and efficient microwave assisted synthesis of several ethyl-quinolon-4-one-3-carboxylates and quinolon-4-one-3-carboxylic acids has been developed. The 3-carboethoxy quinolones are easily obtained in a one-pot procedure through the cyclization of aminomethylenemalonate intermediates obtained by reaction of different p-substituted anilines and diethyl-ethoxymethylenmalonate. These quinolones are then irradiated under base hydrolysis conditions to get the carboxylic acids through a very fast and clean approach
