INFIQC 05475
INSTITUTO DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Unidad Ejecutora - UE
artículos
Título:
Coumarin metabolic routes in Aspergillus spp.
Autor/es:
CELESTE AGUIRRE-PRANZONI; ALEJANDRO A. ORDEN; FABRICIO R. BISOGNO; CARLOS E. ARDANAZ; CARLOS E. TONN; MARCELA KURINA-SANZ
Revista:
Fungal Biology
Editorial:
Elsevier
Referencias:
Lugar: Amsterdam; Año: 2011 vol. 115 p. 245 - 252
ISSN:
1878-6146
Resumen:
Coumarin metabolism by several Aspergillus strains was studied. Aspergillus ochraceus andAspergillus niger carried out the reduction of the C3-C4 double bond to yield dihydrocoumarinin 24 h. Meanwhile, the first strain did not transform dihydrocoumarin after 7 d,A. niger demonstrated to have two divergent catabolic pathways: (a) the lactonemoiety opening and further reduction of the carboxylic acid furnishing the primary alcohol2-(3-hydroxypropyl)phenol and, (b) the hydroxylation of the aromatic ring of dihydrocoumarinat a specific position to give 6-hydroxy-3,4-dihydrochromen-2-one. Aspergillus flavusdid not perform double bond reductions, and only produced oxygenated metabolites,mainly 5-hydroxycoumarin. Enzyme-specific inhibitors and a coumarin analogous wereuseful to confirm the A. niger catabolic route.
