SPEAKER: Participation of TRPV1 osmosensitive channel in the control of sodium appetite

A. GODINO

Congreso; II Pan American Congress of Physiological Sciences; 2019

Changes in body water/sodium balance are tightly controlled by central and peripheral osmo?sodium receptors among others, which trigger the activity of a central network that mainly release vasopressin and/or aldosterone, increase renal sympathetic nerve activity, and induce thirst and sodium appetite. The main central osmoreceptive neurons are in the circumventricular organs of the lamina terminalis, i.e. the organum vasculosum of the lamina terminalis (OVLT), the subfornical organ (SFO) and along the hypothalamic magnocellular cells. It has been postulated that their intrinsic osmosensitivity is mediated in part by different types of channels as TRPV1, TRPV4. Our results are focused on the participation of the TRPV1 channel in the regulation of sodium appetite. For this purpose we used Wistar rat and a TRPV1 KO mouse models. Both were sodium depleted and we analyzed behavioral, renal and plasma responses. We also determined the brain expression of osmotic channels as TRPV1, TRPV4; sodium channels as NaX and angiotensinergic type I receptor along of SFO and OVLT. In conclusion our results suggest that the TRPV1 channels are involved in the osmoregulatory processes after acute body sodium depletion possibly to modulate brain osmo/sodiumreception and renal and intake responses.