Sex chromosome complement effect on sexually dimorphic brain and kidney angiotensin receptors expression.

DADAM, F.; CAEIRO, XE; VIVAS, L

Ribeirao preto, san Pablo.

Simposio; Behavioural, autonomic and neuroendocrine mechanisms regulating homeostasis: a lifelong perspectives?.Symposio en el Congreso organizado por la Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo.; 2016

Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo.

SEX CHROMOSOME COMPLEMENT EFFECT ON SEXUALLY DIMORPHIC BRAIN AND KIDNEY ANGIOTENSIN RECEPTORS EXPRESSION Laura Vivas, Florencia M. Dadam and Ximena E. Caeiro.Instituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC-CONICET-Universidad Nacional de Córdoba, Córdoba, ArgentinaThe present study aimed to define whether sex chromosome complement (SCC) may differentially modulate sex differences in basal ANG II and ANG-(1-7) receptor expression of kidney and specific brain nuclei involved in cardiovascular homeostasis. For this purpose, we used the "four core genotypes" mouse model, in which the effect of gonadal sex (testes vs. ovaries) and sex chromosome complement (XX vs. XY) are uncoupled, allowing comparisons of sexually dimorphic traits between XX and XY females as well as in XX and XY males. Kidney tissue and fore/hindbrain nuclei were collected from gonadectomized male (XX and XY) and female (XX and XY) mice and relative gene expression of Agtr1a, Agtr2, and Mas receptors were assessed using quantitative real time-PCR. Statistical analysis of the subfornical organ data demonstrated that, regardless of gonadal status, mice with the XY-sex chromosome complement showed a greater Agtr1a expression than those with XX {F(1,20)=4.38; p