Relationship between thyroid hormones levels and alcohol consumption

PAUTASSI R.M.; RUIZ P; CALLIARI A

Buenos Aires

Congreso; 2nd Congress of the Federation of Latin-American and Caribbean Societies for Neuroscience (FALAN); 2016

SAN

Little is known about the relationship between alcohol consumption and thyroid hormones levels. The present study analyzed alcohol consumption and thyroid activity in depressed male and female adolescent rats, treated or not with an antidepressant. Wistar rats were given reserpine (RES, 0.0 or 1.0 mg/kg, IP) for 4 days and then were treated with fluoxetine (FLUOX, 0 or 10 mg/kg, IG) for 4 additional days. RES depletes the brain of catecholamines and 5-hydroxytryptamine, and induces significant behavioral depression; whereas FLUOX is a selective serotonin reuptake inhibitor. Half of the animals were subsequently sacrificed for measurement of thyroid activity via RIA and the other half were submitted to an alcohol consumption, two-bottle, test during 5 days [i.e., water vs. 3% (day 1) 4% (days 2-4) or 5% (day 5) ethanol]. Reserpine treatment significantly increased T3 levels (p