INIMEC - CONICET 05467
INSTITUTO DE INVESTIGACION MEDICA MERCEDES Y MARTIN FERREYRA
Unidad Ejecutora - UE
artículos
Título:
IGF-1 receptor is essential for the establishment of hippocampal neuronal polarity.
Autor/es:
SOSA, L; DUPRAZ, S. QUIROGA, S.; LAURINO, L.; BOLLATI, F.; BISBAL, M.; CACERES, A.; PFENNINGER, K.; QUIROGA, S.
Revista:
NATURE NEUROSCIENCE.
Editorial:
Nature Publishing Group
Referencias:
Año: 2006 vol. 9 p. 993 - 995
ISSN:
1097-6256
Resumen:
How a neuron becomes polarized remains largely unknown. The results shown in this communication indicate that an essential step in the establishment of hippocampal neurons polarity and in the initiation of axonal outgrowth is the activation of the PI3k-Cdc42 pathway by the IGF-1 receptor, but not by the tyrosine kinase receptors TrkA or B.
