Copper and Zinc Enriched Mycelium of Agaricus blazei Murrill. Bioaccumulation and Bioavailability.

RABINOVICH, MAIA; FIGLAS, DÉBORA; DELMASTRO, SILVIA; CURVETTO, NÉSTOR

Journal of Medicinal Food

Mary Ann Liebert, Inc.

Año: 2007 vol. 10 p. 175 - 183

1096-620X

Agaricus blazei is an edible mushroom with medicinal properties. To obtain organic combinations of potencial utility as a food dietary supplement, the accumulation and potential bioavailability of copper (Cu) and zinc (Zn) on mycelium grown in the presence of these metals were studied. At 400 ppm, the mycelium accumulated 449 and 163 times the basal content of Cu and Zn, respectively. When mycelia cultivated with nonmycotoxic concentrations of Cu or Zn (100and 200 ppm) were subjected to sequential chemical extraction and simulated gastrointestinal digestion, close to 90% of the metals accumulated in the available nonresidual fraction, which was similar to or better than the values found in two commercial supplements. The solubility in the simulated digestive fluids was 30–34% and 18–33%, i.e., 60–98% and 9–11% of the recommended daily intake for Cu and Zn, respectively, with only 1 g of mycelium.