POLYELECTROLYTE-DRUG MATERIALS FOR NASAL AND PULMONAR ADMINISTRATIONS OBTAINED BY SPRAY-DRYING: A REVIEW

CESCHAN, NAZARETH ELIANA ; MANZO RUBEN; PIÑA, JULIANA; BUCALÁ, VERÓNICA; RAMIREZ RIGO, MARÍA VARÓNICA

Rosario

Congreso; II Reunión Internacional de Ciencias Farmacéuticas; 2012

The acid-base interaction between polyelectrolytes (PE) and ionizable drugs (D) may modify stability, solubility, dissolution or permeation of therapeutic agents. This strategy is a valuable resource to improve drug bioavailability or reduce side effects.(1) The PE-D complexes can be obtained in solution, dispersion or in solid state.(2) Regarding particulate systems solids forms, the design of powders with controlled properties (e.g., respirable particles) is a research area of high activity and importance.(3) Particularly, nasal and pulmonary administrations are receiving great attention as non-invasive drug delivery routes. However, the performance of the delivery system relies on, among other aspects, inhaler design, air flow generated by the patient and the powder formulation and properties. The powder properties (such as size, shape, specific surface area, density and crystallinity) can be adjusted by selecting adequate formulations, processes and operating conditions.(4) Spray-drying is an interesting option because it is a simple, continuous and scalable technique.(5) In this context, the aim of this work is to review scientific reports in order to determine the potentiality of obtaining particles of PE-D complexes by spray-drying for nasal and pulmonary administrations and to highlight the main achievements and challenges in the area.