Novel Hyaluronan-Itaconic Acid-Glutaraldehyde Crosslinked Biofilms

CALLES, JAVIER ADRIÁN; RESSIA, JORGE; LLABOT, JUAN MANUEL; PALMA, SANTIAGO DANIEL; VALLÉS, ENRIQUE MARCELO

Bahía Blanca

Simposio; IX Simposio Argentino de Polímeros (SAP) 2011; 2011

PLAPIQUI

The hyaluronic acid sodium salt, also known as hyaluronan (HA), is a naturally occurring high molecular mass linear biopolymer, consisting of alternating units of N-acetyl-â-D-glucosamine and â-D-glucuronic acid, with reactive carboxyl groups. It is a biodegradable, biocompatible, non toxic, non immunogenic and non inflammatory biomaterial. The total amount of HA in the adult human has been estimated to be 11 ? 17 g (Laurent and Reed, 1991). It is distributed in the human body forming part of synovial fluid, extracellular matrix of biological tissues, skin, umbilical cord and vitreous humor; and widely used in medical practice in many pathological conditions such as osteoarthritis, wound repair and eye surgery (Ambrosio et al., 1999; Balazs and Denlinger, 1993; Borzacchiello et al., 2005; Brown and Jones, 2005; Chen and Abatangelo ,1999).