Study of the influence of different factors affecting albendazole loading on SBA-15 carrier by Box-Behnken design

M. N. PEDERNERA; BUCALÁ, VERÓNICA; BONNE, MAGALI; GALLO LOREANA; ADROVER, M. ESPERANZA; LEBEAU, BÉNÉDICTE

Otro; 6ta Reun. Int. Ciencias Farm. (RICiFa 2020+1),; 2021

Albendazole (ABZ) is an antiparasitic drug that belongs to the BSC II classification.Mesoporous materials loaded with poor soluble drugs (BSC II) became an interesting strategy toincrease their solubility/dissolution rate as the drug crystalline state changes into an amorphous one. However, high drug loading into mesoporous materials still constitutes a challenge. The purpose of this work was to study the influence of different factors affecting ABZ loading on the mesoporous carrier SBA-15. The following factors: temperature (25, 37.5 and 50 ºC), soaking time (24, 48 and 72 h) and SBA-15 mass (83.2; 167.6 and 252.0 mg) were analyzed by a Box-Behnken design. The drug loading experiments were done by the immersion method and the amount of loaded ABZ was quantified by elemental analysis. The loading conditions of 24 hs, 37.50 ºC and 83.2 mg SBA-15 allowed the maximum drug loading (35.84 %, w/w). As the SBA-15 mass and time decreases, the percentage of ABZ loading increases. The SBA-15 mass had the highest significant influence on this response. Therefore, these results show the relevant effect of the loading conditions on the drug loading and the requirement to optimize these parameters.