Chapter 36: Inference of Gene Regulatory Networks based on Association Rules

GALLO, CRISTIAN A.; CARBALLIDO, JESSICA A.; PONZONI, IGNACIO

Biological Knowledge Discovery Handbook: Preprocessing, Mining and Postprocessing of Biological Data

Wiley

Lugar: Hoboken, New Jersey; Año: 2011;

This chapter focuses on gene regulation and the ways that transcriptome data can be used to unravel the complex relationships between the genes that comprise a GRN. In particular, it describes the main topics that must be considered in the field of ARs mining for reverse engineering of GRNs, and presents the state-of-the art techniques currently available in the literature. The organization of the chapter is as follows. In Section 2 the central concepts about ARs mining for GRN reconstruction together with various other relevant issues are presented and discussed.