PLAPIQUI   05457
PLANTA PILOTO DE INGENIERIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
Thermoresponsive hydrogels from alginate-based graft copolymers
Autor/es:
M. M. SOLEDAD, LENCINA; ZACHAROULA, IATRIDI; MARCELO A., VILLAR; CONSTANTINO, TSITSILIANIS
Revista:
EUROPEAN POLYMER JOURNAL
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2014 vol. 61 p. 33 - 44
ISSN:
0014-3057
Resumen:
Three samples of sodium alginate grafted by amino-terminated PNIPAM (low and high molecular weight poly(N-isopropylacrylamide)) and a random P(NIPAM-co-NtBAM) (NtBAM: N-tertiary butyl acrylamide) copolymer, were synthesized via the carbodiimide chemistry and their temperature-induced hydrogelation capability was evaluated by rhe- ology. All the samples showed thermothickening behaviour depending on concentration, ionic strength and hydrophobic comonomer content, incorporated to the PNIPAM thermo-sensitive pendant chains. The main result of this study was that a slight hydropho- bic enrichment (just 15 mol% NtBAM) of PNIPAM was sufficient to shift the gelation tem- perature well below the physiological temperature at 32 ?C and at the lowest polymer concentration studied (i.e. 10 wt%). The consequence of that was that the ALG-g- P(NIPAM-co-NtBAM) graft copolymer hydrogel exhibited the best rheological thermo- responsive properties and might be used as injectable hydrogel for potential applications in biomedicine. ?