PLAPIQUI 05457
PLANTA PILOTO DE INGENIERIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
Application of Dynamic Optimization Techniques for Poly(B-hydroxybutyrate) Production in a Fed-Batch Bioreactor
Autor/es:
JIMMY A. LÓPEZ-JIMÉNEZ; VERÓNICA BUCALÁ; MARCELO A. VILLAR
Revista:
INDUSTRIAL & ENGINEERING CHEMICAL RESEARCH
Editorial:
AMER CHEMICAL SOC
Referencias:
Lugar: Washington; Año: 2010 vol. 49 p. 1762 - 1769
ISSN:
0888-5885
Resumen:
Poly(-hydroxybutyrate), PHB, is a microbial biopolymer produced by bacteria under unbalanced cultureconditions. Such unbalanced conditions can be easily reached in a fed-batch bioreactor; therefore, it is importantto know the systems behavior as well as its constraints to induce unbalanced conditions that allow theoptimization of feeding profiles and, consequently, PHB productivity. In this work, dynamic optimizationhas been applied to maximize PHB productivity in a fed-batch bioreactor. Optimal feeding profiles of carbonand nitrogen sources, as well as their respective concentrations, were obtained using gPROMS (generalizedprocess modeling system). When there is reliable bioreaction kinetics available, dynamic optimization becomesa very valuable tool for predicting optimal operating conditions to maximize PHB productivity, with aconsiderable reduction in time and experimental costs.
