Dynamic scenario in HTLV-I infection

CHIALVA, ULISES; REARTES, WALTER

Journal of Applied Nonlinear Dynamics

L&H Scientific Publishing

Lugar: Glen Carbon. IL; Año: 2019 vol. 9 p. 349 - 359

2164-6457

In this article we present a model that describes the emerging dynamic scenario of infection with the human T-cell lymphotropic virus (HTLV-I). In this model we incorporate the phase of latency in the infection of the CD4 + lymphocytes, the immune response mediated by CD8 + T lymphocytes and the possible appearance of adult T-cell leukemia (ATL). The proposed model is a six-dimensional, non-linear system of ordinary differential equations that describes the dynamic interactions among different cell types. Several types of biological implications are discussed.