Early LPS-induced ERK activation in retinal pigment epithelium cells is dependent on PIP2-PLC

GIUSTO, N; MATEOS, M.V.; KAMERBEEK, C.; SALVADOR GABRIELA

Data in Brief

Elsevier

Lugar: Atlanta; Año: 2016 vol. 7 p. 423 - 427

2352-3409

This article presents additional data regarding the study ?Thephospholipase D pathway mediates the inflammatory response ofthe retinal pigment epithelium? [1]. The new data presented hereshow that short exposure of RPE cells to lipopolysaccharide (LPS)induces an early and transient activation of the extracellularsignal-regulated kinase (ERK1/2). This early ERK1/2 activation isdependent on phosphatidylinositol bisphosphate-phospholipase C(PIP2-PLC). On the contrary, neither the phospholipase D 1 (PLD1)nor the PLD2 inhibition is able to modulate the early ERK1/2activation induced by LPS in RPE cells.& 2016 The Authors. Published by Elsevier Inc. This is an openaccess article under the CC BY lice