INIBIBB 05455
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE BAHIA BLANCA
Unidad Ejecutora - UE
artículos
Título:
Synthesis and biological evaluation of a new vitamin D2 analogue
Autor/es:
GÁNDARA, Z. ; PEREZ, M.; SALOMÓN, D.G.; FERRONATO, M.J.; FERMENTO, M.E.; CURINO, A.C.; FACCHINETTI, M.M.; GOMEZ, G.; FALL, Y.
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2012 vol. 22 p. 6276 - 6279
ISSN:
0960-894X
Resumen:
A new vitamin D2 analogue was synthesized using the Julia-Kocienski olefination. It has antiproliferative effects on cell lines from squamous cell carcinomas of colon and head and neck, but is also as hypercalcaemic as calcitriol in vivo
