Efecto protector gástrico del extracto acuoso de las hojas de Smallanthus macroscyphus en modelos de ulceración inducido por etanol

FÉLIX F. TABOADA; NATALIA HABIB; SUSANA GENTA

San Miguel de Tucumán

Jornada; Reunión Conjunta de Sociedades de Biología de la República Argentina; 2015

The wild yacon, Smallanthus macroscyphus (Baker ex Martius) A. Grau is an autochthonous perennial herb distributed from southern Bolivia to northwestern Argentina. The peptic ulcer is an increasing disorder resulting of the imbalance between offensive and defensive factors in the gastric mucosa and the search for new treatments is a current challenge. The aim of the present study was to evaluate the in vivo gastroprotective and antisecretory effects of the aqueous extract of S. macroscyphus leaves. Two models, ethanol and pylorus ligation of induced gastric ulcers in male Wistar rats, were used. The experimental groups (n=6 animals) were: 1-Control group, 2-Positive control group received Sucralfate or Ranitidin (100mg/Kg oral pathway) 3-Aqueous extract treated group with 140mg/kg of S. macroscyphus leaves decoction orally. Mucus content and ulceration parameters (number of ulcers, severity and ulcerated area percentage) were determined. Chemical and microscopic study of gastric contents and histological studies were performed. S. macroscyphus extract caused a significant (p < 0.05) decrease of the ulcerated area, the severity and number of ulcers, conserving the mucus content. There was also a decrease in the volume, free acidity and presence of cellular elements in gastric content respect to the control group; total acidity was not affected. These preliminary results suggest that the wild yacon could have benefical gastroprotective and antisecretory effects. Additional studies are needed to determinate the active compounds and mechanisms involved.