Decoction of smallanthus macroscyphus leaves attenuates stress oxidative in diabetic rats.

SERRA BARCELLONA C.; SÁNCHEZ SS; GENTA SB

San Miguel de Tucumán

Congreso; XXXII Annual Scientific Meeting of the Tucumán Biology Association; XX Annual Scientific Meeting of the Córdoba Biology Society; XXXIII Annual Scientific Meeting of the Cuyo Biology Society; XVII Annual Meeting of the Argentine Biology Society.; 2015

Argentine Biology Society

Increasing evidence has suggested that oxidative stress plays a major role in the pathogenesis of diabetes mellitus complications. In a recent work we demonstrated that decoction of Smallanthus macroscyphus (Baker ex Martius) A. Grau leaves was effective to reduce postprandial glucose and useful in the treatment of diabetic animals. In the present study we evaluated the antioxidant effect of 10% S. macroscyphus leaves decoction (DEC) on antioxidant enzymes and lipid peroxidation in liver and kidney of diabetic rats. Thirty-day treatment with DEC by the oral route significantly decreased the levels of glucose, HbA1c, Cholesterol and Triglycerides in blood and increased body weight gain. While the untreated diabetic rats showed high activities of SOD and CAT, low activity of GPx, reduced concentration of GSH and increased levels of lipid peroxidation in liver and kidney homogenates, these parameters were restored to near normal levels by the treatment. In addition, treated diabetic rats showed a restored histoarchitecture of liver and kidney. These results provide a scientific basis that supports the efficacy of S. macroscyphus leaves treatment to revert oxidative stress and improve glucose metabolism in diabetic animals.