VASCULAR FUNCTION IN CHILDREN WITH LOW BIRTH WEIGHT AND ITS RELATIONSHIP WITH EARLY MARKERS OF CARDIOVASCULAR RISK

CHALA ROSSANA; PERAL DE BRUNO MARIA; CHAILA ZULEMA; CLAUDIO JOO TURONI; BAZÁN DE CASELLA C

Hormone Research in Paediatrics

Karger

Lugar: Besel; Año: 2016 vol. 85 p. 396 - 405

1663-2818

Low birth weight (LBW) increases cardiovascular disease (CVD) risk. However, few studies established its impact at early ages. Aims: To study endothelial function (EF) and arterial stiffness (AS) in children with LBW and its relationship with early markers of CVD risk.Methods: In children with LBW (4-6 years), anthropometric, hemodynamic and laboratory parameters, included HOMA-IR, hs-CRP, adiponectin and leptin, were determined. EF and AS were evaluated by digital pulse plethysmography. Data were compared with children without LBW (control).Results: In both groups, anthropometric and hemodynamic parameters remained within normal limits. Insulin and HOMA-IR had normal values, but they were significantly augmented in LBW. LBW increased leptin and hs-CRP levels. Only in LBW, correlations between anthropometric and laboratory parameters were found. LBW decreased EF (37.5±5.6%; n=53) vs. control (75.0±11.9%; n=33; p