Oxidative stress in women using intrauterine device TCU380A.

ARNAL NATHALIE; TACCONI DE ALANIZ MARÍA J.; MARRA CARLOS ALBERTO

San Miguel de Tucumán. Argentina

Congreso; XLV Reunión Anual de la Sociedad Argentina de Investigación en Bioquímica y Biología Moleuclar; 2009

Sociedad Argentina de Investigación en Bioquímica y Biología Molecular (SAIB)

 Resumen Copper intrauterine device (Cu-IUD) is a highly effective contraceptive method in women, considered the most effective contraceptive strategy now available. Copper ions (Cu) participate in the Häber-Weiss reaction to produce ROS. It is known that an excess of ROS can cause oxidation of crucial biological macromolecules (proteins, lipids, DNA), leading to metabolic damage. Some authors have demonstrated an elevation of Cu plasma concentration in women using Cu-IUD.The purpose of this study was to measure Cu concentration in plasma of women using Cu-IUD and test (i) the effect on the oxidative stress biomarkers, (ii) the levels of Cu transport proteins in plasma - ceruloplasmine (CRP), metallothioneine (MTs)-, and (iii) the status of some liver damage markers, in relation with the time of using the Cu-IUD. Cu concentration was increased in women using Cu-IUD, with respect to the controls, concomitantly with main oxidative stress biomarkers (TBARs, protein carbonyls, glutathione and nitrates+nitrites), hepatic enzymes (LDH, transaminases), MTs and CRP, in a time-dependent way. It is known that the increase of Cu may be in direct relationship with the increase of atherogenic risk and neurodegenerative disease. Thus, the present results show the importance of going into studies about the use of Cu-IUD in order to elucidate the possible risk of employing this contraceptive strategy.