INIBIOLP 05426
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE LA PLATA "PROF. DR. RODOLFO R. BRENNER"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
A hippocampal age-related eleven gene signature conserved across the species.
Autor/es:
LACUNZA E; OUTEIRO T; PARDO J; FRANCELLE L; GOYA RG; ABBA M; MOREL GR
Lugar:
San Diego
Reunión:
Congreso; Neuroscience 2018 Meeting. Society for Neuroscience.; 2018
Institución organizadora:
Society for Neuroscience
Resumen:
We studied age changes in learning and memory, hippocampal morphology and transcriptome in female rats. In the Barnes Maze Task, senile rats displayed significant deficits in both learning and memory parameters. In the hippocampus, there is a dramatic reduction in the neurogenesis rate and a significantly increased number of reactive microglial cells in the senile Stratum Radiatum. Our hippocampal RNA-Seq data showed that several genes involved in the immune response are overexpressed in the hippocampus of senile rats, for example TYROBP, CD11b, C3, CD18, CD4, and CD74.
