Alterations in copper homeostasis and oxidative stress biomarkers in women using the intrauterine device TCu380A

ARNAL, NATHALIE; MARÍA J.T. DE ALANIZ; CARLOS A. MARRA

TOXICOLOGY LETTERS

ELSEVIER IRELAND LTD

Año: 2009 vol. 192 p. 373 - 378

0378-4274

Copper ions participate in the Häber–Weiss reaction to produce ROS, which can be toxic when in excess.The purpose of this study was to measure the copper concentration (Cu) in the plasma ofwomenusing Cu-IUDs and determine (i) the effect of Cu on oxidative stress biomarkers, (ii) the levels of copper transportproteins in the plasma and (iii) the status of some liver damage markers in relation to the length of theintrauterine device use. Thirty-nine controls and 35 T380-IUD users were recruited. Various oxidativestress biomarkers, ceruloplasmin (CRP), metallothioneins (MTs), Cu and enzyme activities involved inliver function were measured in the plasma. The Cu concentration was higher in women with IUDs,concomitantly with time-dependent increases in the main oxidative stress biomarkers (TBARS, proteincarbonyls, glutathione and nitrates + nitrites), hepatic enzymes (LDH and transaminases), MTs and CRP.We concluded that the use of Cu-IUDs for more than 2 consecutive years should be avoided in order toprevent oxidative damage.