CONICET | Buscador de Institutos y Recursos Humanos

Lipid nanoparticles are considered one of the most promising systems for controlled release of therapeuticmolecules highly hydrophobic and with low biodisponibility. Solid lipid nanoparticles and nanostructured lipids carriersare widely seen as the workhorses of drug delivery systems because of low toxicity, enhanced encapsulation capacity,controlled drug kinetic release, easy tailoring and targeting and practicable scale up. A new generation of hybrid lipidnanoparticles has emerged by combining the lipidic properties with polymers, proteins and metallic structures. The mainfeatures of hybrid lipid nanoparticles including popular methods for synthesis and characterization, biological andtoxicological properties, administration routes, drug encapsulation strategies, tailoring and targeting, and potential systemsfor use in biomedicine are described in the present review