INIBIOLP 05426
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE LA PLATA "PROF. DR. RODOLFO R. BRENNER"
Unidad Ejecutora - UE
artículos
Título:
In vitro comparative analysis of antiproliferative activity of essential oil from mandarin peel and its principal component limonene
Autor/es:
MANASSERO CARLOS; JUAN R GIROTTI; MIJAILOVSKY SERGIO; GARCÍA DE BRAVO MARGARITA; POLO, MONICA
Revista:
NATURAL PRODUCT RESEARCH
Editorial:
TAYLOR & FRANCIS LTD
Referencias:
Lugar: Londres; Año: 2012
ISSN:
1478-6419
Resumen:
The effects of the essential oil of mandarin peel (Corrientes, Argentina) and
limonene (its major component) were studied on two human tumour cell lines
growth (lung adenocarcinoma A549 and hepatocarcinoma HepG2). The essential
oil was obtained by cold press and its composition was investigated by gas
chromatography (GC) and GC/mass spectrometry (MS) analysis. The antiproliferative
effect was studied using an MTT assay. Both mandarin essential oil
and limonene tested showed a strong dose-dependent effect on the growth
inhibition of these cell lines. The essential oil was more effective in A549 than in
HepG2 cells and more effective than limonene in both the cases. It is likely that
minor components and limonene of the oil could exert additive or synergistic
effects. Hence, mandarin essential oil could lead to the development of antitumour
agent or complementary and alternative medicines for the treatment of
diverse cancers.
