LIPOSOMES - ADVANCES AND PERSPECTIVES

A. CATALA

nova sciuence publishers

Lugar: London; Año: 2019 p. 350

978-1-78984-495-5

Liposomes were discovered in 1961 by Alec Bangham, a British scientist whostudied blood coagulation. Bangham and RW Horne were testing the new electronmicroscope of the Agricultural Research Council Institute of Animal Physiology,Babraham, Cambridge, England, when they observed for the first time applying thenegative staining technique for the study of the structures of the lipid phase thatthe dispersions of lecithin contained spherulites composed of concentric sheets [1].These images served as the first evidence that the cell membrane was a two-layeredlipid structure. The width of the lipid layer was estimated at 44 Å. Preparations ofphosphatidylcholine-cholesterol of equal molar ratios were described as basicallythe same as phosphatidylcholine alone.A year later, in a Cambridge pub, Weissmann in a discussion with Banghamcalled these structures ?liposomes? in honor of the lysosome, a simple organellewhose latency linked to the structure could be interrupted with detergents andstreptolysins. [2], and that his laboratory had been studying: liposomes can be easilydistinguished from micelles and hexagonal lipid phases by transmission electronmicroscopy by negative staining [3].