Fluoroquinolone Antibiotics Encapsulation in Calcium Phosphate-Nanoliposome for Bacteria Treatment

ALEJANDRO MIÑAN; CATHERINE RODRÍGUEZ; MARÍA LAURA DELL ARCIPRETE; MÓNICA GONZALEZ

Villa Carlos Paz

Encuentro; XIII Encuentro Latinoamericano de Fotoquímica y Fotobiología; 2017

Grupo Argentino de Fotobiologia

Liposomes are self-assembly structures of natural phospholipids which have been under study as drug delivery systems mainly due to their high biocompatibility in terms of composition, size and physicochemical properties [1]. Despite of the fact liposomes are promising for biomedical applications; one of the drawbacks inherent to their structural assembling is the leaking of entrapped molecules before reaching their destiny. Moreover, the liposomes tendency to coalesce, results in a diminution of the efficiency and poorly stable suspensions [2]. As well, the membranes and biological fluids interaction provoke mechanical stress on liposomes designed for drug delivery. The coating of liposomes with biocompatible and biodegradable materials as calcium phosphates (CaP) [3,4] brings stability, rigidity and biocompatibility prolonging the circulation time in biological media. Fluoroquinolones (FQ) are synthetic antibiotics with a broad action against pathogens like Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa, Escherichia coli, etc [5]. The search for a nanostructured system that protects the FQ from external effects and delivers antibiotics in vicinity of pathogens is fundamental to diminish the problems associated with their susceptibility in biological media.