Nanomaterials based on metal-doped hydroxyapatite with potential applications in orthopedic implants

MARÍA LAURA DITTLER; MARÍA LAURA DELL? ARCIPRETE; DONALDO F. MERCADO CASTRO; MÓNICA GONZALEZ

Ciudad autónoma de Buenos Aires

Conferencia; 6th International Conference on Science and Technology of Composite Materials; 2015

Nanomaterials based on metal-doped hydroxyapatite with potential applications in orthopedic implants M.Laura Dittler 1*, M.Laura Dell´Arciprete 1, D. Fabio Mercado1, Mónica C. Gonzalez11: Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), CCT-La Plata-CONICET, Universidad Nacional de La Plata, La Plata, Buenos Aires 1900, Argentina.* mlauradittler@gmail.com - mlauradittler@inifta.unlp.edu.arIn the context of repair of bone tissue, it requires implants bioactive to inducing osteoblast growth and differentiation, and promotes mineralization.The synthetic HAp is in the forefront of research in tissue engineering, but its use is limited due to its high degree of crystallinity which results in a low biodegradability. To increase the osseointegration of the material, a doping strategy of synthetic HAp with metal ions such as Mg2 +, Zn2 + and Fe2+ is used. In this work was synthesized 10% Zn-doped HAP, and 20% Fe-doped HAp. To compare the effects achieved in the structure of the material by the introduction of the metal, HAp was synthesized.The nanoparticles were characterized by HRTEM, FTIR spectroscopy, TGA, XPS, XRD, DLS, Specific Surface Area, Magnetization curves.The synthesis of FeHAp and ZnHAp was optimized by adaptation of the deposition wet chemistry method at a temperature of 80ºC. At this temperature were obtained nanoparticles of FeHAp with superparamagnetic behavior.Nitrogen Adsorption Studies show an increase in the specific area (BET) of the particles of HAp doped with Zn, and this increase is much greater with the introduction of Fe in the structure; this increase may be related to a loss of crystallinity in the samples. XRD studies also showed loss of crystallinity by peak broadening.HApFeHApZnHApMobility (umcm/Vs)0.84 ±0.35-1.97±0.07-0.66±0.35Surface composition (XPS)Ca1P0.7O3.2Ca1P0.85O4.7Fe0.19--Hydrodynamic Diameter (nm)2100±1771976±2002298±586Specific surface área BET(m2 g-1)25.9 ±0.284.44±0.0562.31±0.06Currently we are working on the surface functionalization of the nanoparticles with biomolecules to promote adhesion and cell proliferation.