Silica nanoparticles applications in the biomedical field

AGUSTIN SILVIO PICCO; MATEUS BORBA CARDOSO; LÍVIA MESQUITA DIAS LOIOLA; MICHELLE DA SILVA LIBERATO; LARISSA BRENTANO CAPELETTI

Smart Nanoparticles for Biomedicine

Elsevier

Año: 2018; p. 115 - 129

Nanomedicine, the application of nanoscience and nanotechnology to healthcare, hasemerged in the last two decades as a promising tool for several therapeutic and diagnosticapplications [1]. In this context, a plethora of organic and inorganic nanoparticles havebeen extensively developed to precisely act as drug delivery, bioimaging, bactericidal,virucidal, and vaccination systems [2]. Among them, silica-based nanomaterials exhibitmany desirable features that are attractive to nanomedicine. From a chemical point ofview, the main advantages of silica nanoparticles (SiO2NPs) include tunable size andporosity, simple and versatile surface functionalization, facile and cost-effective production,and easy large-scale synthesis [3,4]. In addition, from a biological and medical perspective,SiO2NPs have shown limited toxicity and good biodegradability, making themgood candidates for in vivo applications