Electrochemically Designed Self- Assembled Monolayers for the Selective Immobilization and Release of Ligands, Proteins, and Cells

O. AZZARONI; R.C. SALVAREZZA

Handbook of Biofunctional Surfaces

Pan Stanford Publishing Pte. Ltd.

Año: 2013; p. 99 - 137

Physicists, chemists, and biologists are becoming increasingly interested in electrochemistry as a toolkit with which to tune and modulate the biological activity of biofunctional SAMs. However, the interdisciplinary nature of biointerface science demands the convergence of biology, organic chemistry, and surface science, together with electrochemistry, to take advantage of the strengths of each discipline so as to develop a highly functional SAM displaying electrochemically driven, well-defined biological activity. Herein a critical review of relevant examples from the literature illustrating the use of electrochemistry as a key enabler to modulate the biological activity of SAMs is presented. From these examples it is hoped that the reader will get an understanding not only of the versatility of electroactive SAMs to promote organic reactions on surfaces but also of the way in which electrochemistry can open new opportunities to design multifunctional biological interfaces.