Sustainable Synthesis of Flavonoid Derivatives, QSAR Study and Insecticidal Activity Against the Fall Armyworm, Spodoptera frugiperda (Lep.: Noctuidae)

G. P. ROMANELLI; E. VIRLA; P. R. DUCHOWICZ; A. L. GADDI; D. M. RUIZ; D. O. BENNARDI; E. V. ORTIZ; J. C. AUTINO

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

AMER CHEMICAL SOC

Año: 2010

0021-8561

A simple, clean, solvent-free preparation of flavones by the use of a silica-supported Preyssler heteropolyacid as reusable catalyst is described. High selectivity and very good yields (87-94%) were obtained in short reaction times (7-13 min). Bioassays for insecticidal activity against Spodoptera frugiperda were carried out with a set of flavones. Bioassays showed that some of the flavones had moderate insecticidal activity. Quantitative structure-activity relationships were established on the available data with the purpose of predicting the insecticidal activity of a number of structurally related flavones. A relationship between the molecular structure and biological activity is proposed.