INIFTA 05425
INSTITUTO DE INVESTIGACIONES FISICO-QUIMICAS TEORICAS Y APLICADAS
Unidad Ejecutora - UE
artículos
Título:
SAXS Study of Polyurethane/Poly(2-(diethyl amino)ethyl Methacrylate) Blends for Drug Delivery Applications
Autor/es:
ECHEVERRÍA, M.G.; PARDINI, O.R.; PERUZZO, P.J.; AMALVY, J.I.
Revista:
Activity Report 2010 - Brazilian Synchrotron Light Laboratory
Editorial:
Laboratorio Nacional de Luz Sincrotrón
Referencias:
Año: 2011 p. 1 - 2
ISSN:
1518-0204
Resumen:
pH-sensitive materials that can change on application of an external stimulus have recently attracted particular attention in the context of drug delivery and tissue engineering. Aprevious study of poly(2-(diethyl amino)ethyl methacrylate) (PDEA)-based microgels shows that unlike high Tg microgels they are soft and film forming. However, dependingon the environmental conditions, films formed from pure PDEA crosslinked microgels could be hard and brittle. A simple way to modify this is by blending the PDEA with a goodfilm-forming polymer like polyurethanes (PU). Our group has been working for a long time with PU and PU/acrylate systems including blends and hybrids. In this work themorphology of blends PU/PDEA with different acrylic content and containing different model drugs was studied using SAXS.
