Computational package of a mechanical cell-based model to study tissues in developmental and regenerating conditions

ALBERTO SEBASTIÁN CECCARELLI; OSVALDO CHARA; AUGUSTO BORGES; EMANUEL CURA COSTA; HUGO ARIEL ALVAREZ

Buenos Aires

Congreso; Latin American Society for Developmental Biology Meeting; 2019

Latin American Society for Developmental Biology

The dynamical aspects of tissue structures are crucial during development and regeneration. Quantitative approaches are needed to model such processes and provide high temporal and spatial resolution. The Vertex model is one of these approaches. In this modeling strategy, cells are modeled as polygons which vertices move according to the interaction between them. Here we present a computational package that implemented a 2D Vertex Model in Python which is user friendly: SysVert. It is able to successfully simulate processes like cell proliferation or apoptosis efficiently as well as allows for multi-scale systems biology strategies.